assunta.carpinelli * ibfm.cnr.it

Nuclear Medicine Department and PET Centre, San Raffaele Hospital - Milan, Italy

Postal address:

Department of Nuclear Medicine and PET Centre, San Raffaele Ospital - Via Olgettina, 60 - 20132 Milan, Italy.
Tel. +39 02 2643.3630 - Fax +39 02 26415202

Chemistry: N Synthesis of precursors and standards and chemical characterization using Mass Spectrometry and NMR. These molecules are used for studying dopaminergic and colinergic neurotransmission systems by Positron Emission Tomography (PET).
Radiochemistry: Synthesis, development of new chromatographic methods and quality control of new radioligands labelled with [18F] Fluoride, [11C] Carbon ( radioisotopes positron emitters) and [123I] Iodine (single photon emitter).

Representative publications:

Carpinelli A, Mosca A, Bonini PA. Evaluation of a new semi automated high-performance liquid chromatography method for glycosylated haemoglobins. J. of Automatic Chemistry 1986; 8 (4): 192-196.

Messa C, Volontè MA, Fazio F, Zito F, Carpinelli A, D’Amico A, Rizzo G, Moresco RM, Paulesu E, Franceschi M, Lucignani G. Differential distribution of striatal [123I] b-CIT in Parkinson’s disease and progressive supranuclear palsy, evaluated with single – photon emission tomography. Eur J Nucl Med, 1998; 25: 1270-1276

Carpinelli A, Matarrese M, Moresco RM, Simonelli P, Todde S, Magni F, Galli Kienle M, Fazio F. Radiosynthesis of [123] b CIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain. Appl Radiat and Isotopes, 2001; 54 (1): 93-95.

Moresco RM, Volontè MA, Messa C, Gobbo C, Galli L, Carpinelli A, Rizzo G, Panzacchi A, Franceschi M, Fazio F. New perspective on neurochemical effects of amantadine in the brain of parkinsonian patients: [11C] raclopride study. J Neural Transm, 2002; 109: 1265-1274.

Lucignani G, Gobbo C, Moresco RM, Antonini A, Panzacchi A, Bonaldi L, Carpinelli A, Caraceni T, Fazio F. The feasibility of statistical parametric mapping for the analysis of positron emission tomography studies using 11C 2-b- carbomethoxy-3-b- (4- fluorophenyl)- tropane in patients with movement disorders. Nucl. Med Commun, 2002; 23: 1047- 1055.