Research Topics

• • Cancer Metabolism
  • Metabolomics and Biomarkers
  • Systems Metabolomics
  • Metabolomics and clinical oncology
  • Metabolic Disease

CV

National Collaborations

• • Prof. Salvatore Pece Istututo Europeo di Oncologia, Milano
  • Dr. Angela Bonura e Dott.ssa Annalisa Pinsino IRIB-CNR Palermo
  • Prof. Cesare Indivere DiBest-UNICAL, IBIOM-CNR
  • Prof. Gian Mario Sambuceti Ospedal San Martino, Genova

International Collaborations

• • Dr. Christian Metallo University of California, San Diego
  • Prof. Soldano Ferrone, Harvard Medical School, Massachusetts General Hospital

Selected recent publications

• • Patent application PCT/EP2019/079843-P019742WO-01 (16836PTWO) “COMBINATORIAL DRUG TREATMENT FOR CANCER”.
• • Damiani C, Gaglio D, Sacco E, Alberghina L, Vanoni M. Systems metabolomics: from metabolomic snapshots to design principles. Curr Opin Biotechnol. 2020 Apr 8;63:190-199. doi: 10.1016/j.copbio.2020.02.013.
• • Alijagic A, Gaglio D, Napodano E, Russo R, Costa C, Benada O, Kofroňová O, Pinsino A. Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity. J Hazard Mater. 2020 Feb 15;384:121389. doi: 10.1016/j.jhazmat.2019.121389.
• • Valtorta S, Lo Dico A, Raccagni I, Gaglio D, Belloli S, Politi LS, Martelli C, Diceglie C, Bonanomi M, Ercoli G, Vaira V, Ottobrini L, Moresco RM. Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models. Oncotarget. 2017 Dec 6;8(68):113090-113104. doi: 10.18632/oncotarget.23028.
• • Damiani C, Colombo R, Gaglio D, Mastroianni F, Pescini D, Westerhoff HV, Mauri G, Vanoni M, Alberghina L. A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect. PLoS Comput Biol. 2017 Sep 28;13(9):e1005758. doi: 10.1371/journal.pcbi.1005758.
• • Daniela Gaglio, Silvia Valtorta Marilena Ripamonti, Marcella Bonanomi, Chiara Damiani, Sergio Todde, Alfredo Simone Negri, Francesca Sanvito, Fabrizia Mastroianni, Antonella Di Campli, Gabriele Turacchio, Giuseppe Di Grigoli, Sara Belloli, Alberto Luini, Maria Carla Gilardi, Lilia Alberghina, Rosa Maria Moresco “Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: A PET imaging and metabolomics-mass-spectrometry study” Oncotarget. 2016 Jul 7. doi: 10.18632/oncotarget.10470.
• • Daniela Gaglio, Silvia Valtorta Marilena Ripamonti, Marcella Bonanomi, Chiara Damiani, Sergio Todde, Alfredo Simone Negri, Francesca Sanvito, Fabrizia Mastroianni, Antonella Di Campli, Gabriele Turacchio, Giuseppe Di Grigoli, Sara Belloli, Alberto Luini, Maria Carla Gilardi, Lilia Alberghina, Rosa Maria Moresco “Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: A PET imaging and metabolomics-mass-spectrometry study” Oncotarget. 2016 Jul 7. doi: 10.18632/oncotarget.10470.
• • Lilia Alberghina, Daniela Gaglio, Rosa M. Moresco, Maria C. Gilardi, and MarcoVanoni “A systems biology road map for the discovery of drugs targeting cancer cell metabolism” Curr Pharm Des. 2014;20(15):2648-66.
• • Lilia Alberghina, Daniela Gaglio, Cecilia Gelfi, Rosa M. Moresco, Giancarlo Mauri, Paola Bertolazzi, Cristina Messa, Maria C. Gilardi, Ferdinando Chiaradonna and Marco Vanoni “Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodelling” Front Physiol. 2012;3:362. 2012 Sep 12.
• • Daniela Gaglio, Christian M. Metallo, Paulo A. Gameiro, Karsten Hiller, Lara Sala Danna, Chiara Balestrieri, Lilia Alberghina, Gregory Stephanopoulos and Ferdinando Chiaradonna “Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth”. Mol Syst Biol. 2011 Aug 16;7:523.
• • Ferdinando Chiaradonna., RosaMaria Moresco, Cristina Airoldi, Daniela Gaglio, Roberta Palorini, Francesco Nicotra, Cristina Messa and Lilia Alberghina. “From cancer metabolism to new biomarkers and drug targets”. Review J. Biotechnology Advances, 2011 Jul 23.