Research Topics

Molecular imaging techniques of small animals, in particolar Positron Emission Tomography (PET), Single Photon Computed Emission Tomography (SPECT) e Computed Tomography (CT).

Preclinical animal models of tumor and neurodegeneration.

Evaluation of pharmacological treatments or nanoparticles, antibodies and peptides-based treatments.

Ex vivo (autoradiography) and in vitro (tissue sampling and cellular uptake) nuclear medicine techniques.

CV

National Collaborations

Università degli Studi di Milano – Bicocca, Dipartimento di Medicina e Chirurgia, Monza;

Ospedale San Raffaele, Unità di Medicina Nucleare, Milano;

International Collaborations

Dr. Anna Rosell, Neurovascular Research Laboratory of VHIR, Barcelona;

Prof. Andreas H. Jacobs, European Institute for Molecular Imaging (EIMI), University of Münster

Selected recent publications

Belloli S, Morari M, Murtaj M, Valtorta S, Moresco RM and Gilardi MC. Translation imaging in Parkinson’s disease: focus on neuroinflammation Review, Accepted from Front. Aging Neurosci. 2020.

Besusso D, Schellino R, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Bocchi VD, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A, Cattaneo E. Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease. Stem Cell Reports. 2020 Apr 8. pii: S2213-6711(20)30108-9. doi: 10.1016/j.stemcr.2020.03.018.

Murtaj V, Belloli S, Di Grigoli G, Pannese M, Ballarini E, Rodriguez-Menendez V, Marmiroli P, Cappelli A, Masiello V, Monterisi C, Bellelli G, Panina-Bordignon P, Moresco RM. Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. Front Aging Neurosci. 2019 Nov 5;11:299. doi: 10.3389/fnagi.2019.00299. eCollection 2019.

Raccagni I, Belloli S, Valtorta S, Stefano A, Presotto L, Pascali C, Bogni A, Tortoreto M, Zaffaroni N, Daidone MG, Russo G, Bombardieri E, Moresco RM. [18F]FDG and [18F]FLT PET for the evaluation of response to neo-adjuvant chemotherapy in a model of triple negative breast cancer. PLoS One. 2018 May 23;13(5):e0197754. doi: 10.1371/journal.pone.0197754.

Belloli S, Zanotti L, Murtaj V, Mazzon C, Di Grigoli G, Monterisi C, Masiello V, Iaccarino L, Cappelli A, Poliani PL, Politi LS, Moresco RM. 18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis. J Neuroinflammation. 2018 Feb 5;15(1):33. doi: 10.1186/s12974-017-1044-x.

Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fucà E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E. Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1234-E1242. doi: 10.1073/pnas.1611473114.

Rainone P, Riva B, Belloli S, Sudati F, Ripamonti M, Verderio P, Colombo M, Colzani B, Gilardi MC, Moresco RM, Prosperi D. Development of 99mTc-radiolabeled nanosilica for targeted detection of HER2-positive breast cancer. Int J Nanomedicine. 2017 May 2;12:3447-3461. doi: 10.2147/IJN.S129720.

Belloli S, Pannese M, Buonsanti C, Maiorino C, Di Grigoli G, Carpinelli A, Monterisi C, Moresco RM, Panina-Bordignon P. Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice. Neurobiol Aging. 2017 May;53:159-168. doi: 10.1016/j.neurobiolaging.2017.01.010. Epub 2017 Jan 17.

Di Grigoli G, Monterisi C, Belloli S, Masiello V, Politi LS, Valenti S, Paolino M, Anzini M, Matarrese M, Cappelli A, Moresco RM. Radiosynthesis and Preliminary Biological Evaluation of [18F]VC701, a Radioligand for Translocator Protein. Mol Imaging. 2015;14. doi: 10.2310/7290.2015.00007.

Belloli S, Brioschi A, Politi LS, Ronchetti F, Calderoni S, Raccagni I, Pagani A, Monterisi C, Zenga F, Zara G, Fazio F, Mauro A, Moresco RM. Characterization of biological features of a rat F98 GBM model: a PET-MRI study with [18F]FAZA and [18F]FDG. Nucl Med Biol. 2013 Aug;40(6):831-40. doi:10.1016/j.nucmedbio.2013.05.004.