Research Topics

• • In vitro and in vivo studies on different radiobiological models (immortalized and primary cells of breast cancer and glioblastoma multiforme; preclinical models using mice or Zebrafish models), subjected to different types of beam (photons, protons or combined treatments with radiosensitizing drugs /molecules).
  • Definition of dose-response curves, LQ model and derivation of the α/β parameters.
  • Study of the genomic response to ionizing radiation associated with tumor histopathological profile.
  • Use of animal models for the study of RBE, TCP / NTCP and molecular imaging studies.

CV

National Collaboration

• • Southern National Laboratory ; Trento TIFPA Center (INFN)
  • Stebicef Department, Aten Center (UNIPA)
  • Fondazione G. Giglio di Cefalù (PA)

International Collaborations

• • Prof. A. Ristic Fira Vinca Institute of Nuclear Science, University of Belgrado
  • Prof. Katalin Hideghéty eli-alps.hu/ Non-Profit Ltd. Szeged University
  • Dr. Daniele Margarone, Eli Beamline, Dolni Brezany, Praha

Selected Recent Publications

• • Russo G, Pisciotta P, Cirrone GAP, Romano F, Cammarata FP, Marchese V, Forte GI, Lamia D, Minafra L, Bravatá V, Acquaviva R, Gilardi MC, Cuttone G. Preliminary study for small animal preclinical hadrontherapy facility. Nuclear Inst. and Methods in Physics Research, A. 2017; 846: 126-134.
• • Bravatà V, Cava C, Minafra L, Cammarata FP, Russo G, Gilardi MC, Castiglioni I, Forte GI. Radiation-induced gene expression changes in high and low grade breast cancer cell types. Int J Mol Sci. 2018 Apr 4;19(4).
• • Minafra L, Bravatà V, Cammarata FP, Russo G, Gilardi MC, Forte GI. Radiation Gene-expression Signatures in Primary Breast Cancer Cells. Anticancer Res. 2018 May;38(5):2707-2715.
• • Bravatà V, Minafra L, Cammarata FP, Pisciotta P, Lamia D, Marchese V, Manti L, Cirrone GA, Gilardi MC, Cuttone G, Forte GI, Russo G. Gene expression profiling of breast cancer cell lines treated with proton and electron radiations. Br J Radiol. 2018 Jun 11:20170934. https://doi.org/10.1016/j.engappai.2019.02.005.
• • Pisciotta P, Cammarata FP, Stefano A, Romano F, Marchese V, Torrisi F, Forte GI, Cella L, Cirrone GAP, Petringa G, Gilardi MC, Cuttone G, Russo G. Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility. Phys Med. 2018 Oct; 54:173-178.
• • Bravatà V, Cammarata FP, Minafra L, Pisciotta P, Scazzone C, Manti L, Petringa G, Cirrone GAP, Cuttone G, Gilardi MC, Forte GI, Russo G. “Proton-irradiated breast cells: molecular points of view”. IJ Radiat Res. 2019 May 28.
• • Bravatà V, Cammarata FP, Minafra L, Musso R, Pucci G, Spada M, Fazio I, Russo G and Forte GI. Gene Expression Profiles Induced by High-dose Ionizing Radiation in MDA-MB-231 Triple Negative Breast Cancer Cell Line”. Cancer Genomics Proteomics. 2019 Jul-Aug;16(4):257-266.
• • Minafra L, Porcino N, Bravatà V, Gaglio D, Bonanomi M, Amore E, Cammarata FP, Russo G, Militello C, Savoca G, Baglio M, Abbate B, Iacoviello G, Evangelista G, Gilardi MC, Bondì ML, Forte GI. “Radiosensitizing effect of curcumin-loaded lipid nanoparticles in breast cancer cells”. Sci Rep. 2019 Jul 31;9(1):11134.
• • Cammarata FP, Torrisi F, Forte GI, Minafra L, Bravatà V, Pisciotta P, Savoca G, Calvaruso M, Petringa G, Cirrone GAP, Fallacara AL, Maccari L, Botta M, Schenone S, Parenti R, Cuttone G, Russo G. Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line. Int J Mol Sci. 2019 Sep 24;20(19):4745.
• • Pisciotta P, Costantino A, Cammarata FP, Torrisi F, Marchese V, Cirrone GAP, Petringa G, Forte GI, Minafra L, Bravatà V, Gulisano M, Scopellit F, Cuttone G, Ippolito M, Parenti R, Russo G. Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP. Plos One (In press).